We are happy to present our research collaboration results with the Yixin Zhang lab of BCUBE at TU Dresden, which were recently published in Nature Communications. There, we introduce a significant achievement in the field of chemical library construction using a new self-assembled DNA-encoded chemical library (DEL) method.
The split-and-pool method has been widely used for synthesizing chemical libraries of a large size, but with no meaningful quality control. However, the new T-DEL method developed in this study allows for the creation of an m x l x n-member library through assembling three pre-purified and validated sub-libraries, allowing for much improved quality control measures. This approach has already demonstrated its potential for linker optimization and de novo selections against various targets. This achievement marks a major advancement in the field and offers exciting new possibilities for drug discovery.
For the full publication, please visit: https://www.nature.com/articles/s41467-023-37071-1